Blood-based 8-hydroxy-2′-deoxyguanosine level: A potential diagnostic biomarker for atrial fibrillation
| Autor: | Luciënne Baks, Natasja M.S. de Groot, Jin Li, Eva A.H. Lanters, Marit Wiersma, Bianca J.J.M. Brundel, Deli Zhang, Kennedy S. Ramos, Ad J.J.C. Bogers |
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| Přispěvatelé: | Cardiology, Cardiothoracic Surgery |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Electric Countershock 030204 cardiovascular system & hematology Pulmonary vein Pathogenesis 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Atrial Fibrillation medicine Humans Sinus rhythm Prospective Studies 030212 general & internal medicine Cardiac Surgical Procedures Stage (cooking) business.industry 8-Hydroxy-2'-deoxyguanosine Atrial fibrillation Biomarker Middle Aged Prognosis medicine.disease 8-hydroxy-2ʹ-deoxyguanosine Postoperative atrial fibrillation Cardiac surgery Treatment Outcome 8-Hydroxy-2'-Deoxyguanosine Human and Animal Physiology Fysiologie van Mens en Dier Cardiology DNA damage Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Biomarkers Follow-Up Studies |
| Zdroj: | Heart Rhythm 18 (2021) 2 Heart Rhythm, 18(2), 271-277 Heart Rhythm, 18(2), 271-277. Elsevier |
| ISSN: | 1547-5271 |
| Popis: | Background Recent research findings have revealed a key role of oxidative DNA damage in the pathogenesis of atrial fibrillation (AF). Therefore, the circulating oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) may represent a biomarker for staging AF and identifying patients at risk for AF recurrence and postoperative atrial fibrillation (POAF) after treatment. Objective The purpose of this study was to investigate whether serum levels of 8-OHdG correlate with the stage of AF, recurrence after AF treatment, and onset of POAF after cardiac surgery. Methods In this prospective observational study, 8-OHdG levels were detected by enzyme-linked immunosorbent assay in human serum samples. Blood samples were collected from control patients without AF history; patients with paroxysmal AF and persistent AF undergoing electrical cardioversion or pulmonary vein isolation (PVI); and patients with sinus rhythm (SR) undergoing cardiac surgery. AF recurrence was determined during 12-month follow-up. Univariate and multivariate analyses were used to identify changes in 8-OHdG levels between the groups. Results Compared to the control group, 8-OHdG levels in the patient groups gradually and significantly increased during arrhythmia progression. 8-OHdG levels in AF patients showing AF recurrence after PVI treatment were significantly increased compared to patients without AF recurrence. Moreover, in SR patients undergoing cardiac surgery, 8-OHdG levels were significantly elevated in those showing POAF compared to patients without POAF. Conclusion 8-OHdG level may represent a potential diagnostic biomarker for AF staging as well as for predicting AF recurrence and POAF after treatment. |
| Databáze: | OpenAIRE |
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