Diarrhoea and weight loss in an immunosuppressed patient
| Autor: | Paul Collins, Mark A. Fox, Safa Al-shamma, Martin Lombard, Fiona Campbell |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Diarrhea
medicine.medical_specialty medicine.medical_treatment Colonoscopy Opportunistic Infections Gastroenterology Diagnosis Differential Immunocompromised Host Primary biliary cirrhosis Crohn Disease Weight loss Internal medicine Weight Loss medicine Humans Ascending colon Euthyroid Mean corpuscular volume Aged medicine.diagnostic_test business.industry Immunosuppression Mycophenolic Acid Colitis Ciclosporin medicine.disease Cytomegalovirus Infections Female medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Gut. 59:1225-1225 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.2009.198986 |
| Popis: | A 74-year-old Caucasian female presented with a 12 month history of non-bloody, culture-negative diarrhoea associated with weight loss of 10 kg. She denied any extragastrointestinal manifestations. She had previously undergone orthotopic liver transplantation for primary biliary cirrhosis 12 years ago. Her immunosuppression was mycophenolate mofetil 500 mg twice daily for the past 2 years. She had previously been on ciclosporin but this was discontinued due to renal impairment. Baseline bloods revealed: haemoglobin 9.6 g/dl (mean corpuscular volume (MCV) 85 fl), C-reactive protein 76 mg/l and normal renal and liver biochemistry. She was euthyroid, and coeliac serology was negative. Colonoscopy demonstrated moderate, patchy mucosal inflammation predominantly affecting the proximal colon (figure 1). Multiple biopsies were obtained. Figure 1 Ascending colon. What is the diagnosis? What is the best management? See page 1302 for the answers From the questions on page … |
| Databáze: | OpenAIRE |
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