Sumatriptan provokes coronary artery spasm in patients with variant angina: Possible involvement of serotonin 1B receptor
| Autor: | Ryohei Yoshikawa, Yoshitomo Miyamoto, Masakatsu Shimizu, Hidenari Matsumoto, Satoshi Watanabe, Hideyuki Takaoka, Hiroyuki Masai, Katsuya Hata, Mitsuhiro Yokoyama, Kenji Kanazawa, Hozuka Akita, Toshiro Shinke |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Angina Pectoris Variant Male Agonist medicine.medical_specialty medicine.drug_class Coronary Vasospasm Angina Internal medicine Humans Medicine Platelet activation Sumatriptan business.industry Vascular disease Middle Aged medicine.disease Coronary Vessels Serotonin Receptor Agonists Coronary arteries medicine.anatomical_structure Circulatory system Receptor Serotonin 5-HT1B Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | International Journal of Cardiology. 114:188-194 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2006.01.026 |
| Popis: | Serotonin (5HT) can induce coronary artery spasm (CAS) in patients with variant angina (VA). We have previously reported that 5HT(1B) and 5HT(2A) receptors gene were expressed in human coronary arterial smooth muscle cells and that isolated coronary artery from a patient with VA showed the supersensitivity to sumatriptan (SMT), a 5HT(1B/1D) receptor agonist. The aim of the present study was to determine whether SMT can provoke CAS directly or indirectly through platelet aggregation in patients with VA.We evaluated the effects of intracoronary infusion of graded concentrations of SMT on coronary arteries in 9 patients, including 5 documented VA and 4 participants with atypical chest pain as control.SMT provoked CAS in all patients with VA. SMT could not induce CAS in control. SMT (10(-4) M) caused significant contractions (%diameter of baseline; median [interquartile range], 0 [0-18.4]% in VA, as compared with control (proximal segments; 92.6 [77.9-118.9]%, p0.05 vs. VA, distal segments; 92.9 [65.3-158.5]%, p0.01 vs. VA). In control, minor dilation occurred at SMT concentration up to 10(-5) M. SMT could induce in vitro platelet aggregation neither in healthy subjects nor in patients with VA.These findings suggest that activation of 5HT(1B) receptor by SMT can induce CAS directly in patients with VA without platelet activation. This is the first report directly demonstrating the effect of 5HT(1B) receptor activation on human coronary arteries in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect