Clinical Features and Risk Factors of ICU Admission for COVID-19 Patients with Diabetes

Autor:	Yaoqiu Pi, Feng He, Shuguang Qin, Lin Liu, Xiaomei Huang, Riguang Liu, Kashuai Lin, Liuping Yang, Kaiyuan Hu, Jun Huang, Ming Lei, Lixin Fan, Xinning Shao
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Respiratory rate Article Subject Endocrinology Diabetes and Metabolism Population Aspartate transaminase Diseases of the endocrine glands. Clinical endocrinology law.invention Endocrinology Risk Factors law Internal medicine Diabetes mellitus medicine Humans education Aged Retrospective Studies education.field_of_study biology business.industry COVID-19 Retrospective cohort study Odds ratio Middle Aged RC648-665 medicine.disease Intensive care unit Hospitalization Intensive Care Units Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Alanine transaminase biology.protein Female Symptom Assessment business Research Article
Zdroj:	Journal of Diabetes Research Journal of Diabetes Research, Vol 2020 (2020)
ISSN:	2314-6745
DOI:	10.1155/2020/5237840
Popis:	Introduction. Previous studies of coronavirus disease 2019 (COVID-19) have focused on the general population. However, diabetes (DM) as one of the most common comorbidities is rarely studied in detail. This study is aimed at describing clinical characteristics and determining risk factors of ICU admission for COVID-19 patients with DM. Methods. Data were extracted from 288 adult patients with laboratory-confirmed COVID-19 from Guangzhou Eighth People’s Hospital. Demographic characteristics, laboratory results, radiographic findings, complications, and treatments were collected and compared between DM and non-DM groups. Binary logistic regression was used to identify the risk factors associated with ICU admission for COVID-19 patients with DM or non-DM. Results. COVID-19 patients with DM showed as older ages, higher levels of C-reactive protein (CRP), myoglobin, alanine transaminase (ALT), and aspartate transaminase (AST). They were also more prone to transfer to the intensive care unit (ICU) for treatment. Multiple regression analysis showed that the following were the independent risk factors for COVID-19 patients with DM that received ICU admission: each 1-year increase in age (odds ratio (OR), 1.07; 95% CI, 1.02-1.13;P=0.007), respiratory rate over 24 times per minute (OR, 5.22; 95% CI, 2.26-16.58;P=0.016), HbA1c greater than 7% (OR, 4.58; 95% CI, 1.82-10.55;P=0.012), and AST higher than 40 U/L (OR, 2.96; 95% CI, 1.58-8.85;P=0.022). In addition, each 1-year increase in age (OR, 1.05; 95% CI, 1.01-1.10;P=0.006), diarrhea (OR, 4.62; 95% CI, 2.01-9.36;P=0.022), respiratory rate over 24 times per minute (OR, 5.13; 95% CI, 1.18-16.82;P=0.035), CRP greater than 10 mg/L (OR, 5.19; 95% CI, 1.37-13.25,P=0.009), and TnI higher than 0.03 μg/L (OR, 6.48; 95% CI, 1.17-21.38;P=0.036) were risk factors for ICU admission of COVID-19 patients with non-DM. Conclusions. The older age, respiratory rate over 24 times per minute, HbA1c greater than 7%, and AST higher than 40 U/L were risk factors of ICU admission for COVID-19 patients with diabetes. Investigating and monitoring these factors could assist in the risk stratification of COVID-19 patients with DM at an early stage.
Databáze:	OpenAIRE
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