Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
| Autor: | M. Micic, Jovanka M. Filipović, Edin H. Suljovrujić, Simonida Lj. Tomić, Sava N. Dobić |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Thermogravimetric analysis
gamma-radiation Materials science Biocompatibility 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Microbe penetration chemistry.chemical_compound Polymer chemistry Copolymer Itaconic acid 2-Hydroxyethyl methacrylate Radiation Comonomer Smart hydrogels Dynamic mechanical analysis 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Chemical engineering Self-healing hydrogels 0210 nano-technology |
| Zdroj: | Radiation Physics and Chemistry |
| Popis: | pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|