Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis

Autor: Keith Bowering, David Russell-Jones, Simon Heller, Stewart B. Harris, Bruce W. Bode, Vincent Woo, Milivoj Piletič, Claus Dethlefsen, Chantal Mathieu, Helena W. Rodbard, Vinay Babu
Rok vydání: 2018
Předmět:
Zdroj: Diabetes Therapy
ISSN: 1869-6961
1869-6953
DOI: 10.1007/s13300-018-0553-7
Popis: Introduction The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes. Methods Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI ( 58– 7.5– 30 kg/m2 subgroup. Conclusions In participants with T1D and T2D, treatment differences (for change in HbA1c and overall hypoglycaemia) between mealtime faster aspart and insulin comparators were similar to the corresponding overall analysis across baseline HbA1c and BMI subgroups. The finding of a lower total daily insulin dose in participants with obesity (BMI > 30 kg/m2) and T1D treated with faster aspart, versus those treated with IAsp, may warrant further investigation. Trial Registration ClinicalTrials.gov NCT01831765 (onset 1); NCT01819129 (onset 2); NCT01850615 (onset 3). Funding Novo Nordisk A/S, Søborg, Denmark. Electronic supplementary material The online version of this article (10.1007/s13300-018-0553-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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