Spatial Cytoskeleton Organization Supports Targeted Intracellular Transport
| Autor: | Heiko Rieger, Anne E. Hafner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Quantitative Biology - Subcellular Processes Cytoskeleton organization Biophysics FOS: Physical sciences macromolecular substances Biology Models Biological Cell membrane 03 medical and health sciences Microtubule medicine Molecular Machines Motors and Nanoscale Biophysics Physics - Biological Physics Cytoskeleton Subcellular Processes (q-bio.SC) Actin Physics Narrow escape problem Biological Transport Cell biology 030104 developmental biology medicine.anatomical_structure Biological Physics (physics.bio-ph) Centrosome FOS: Biological sciences Intracellular |
| Zdroj: | Biophysical Journal. 114:1420-1432 |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2018.01.042 |
| Popis: | The efficiency of intracellular cargo transport from specific source to target locations is strongly dependent upon molecular motor-assisted motion along the cytoskeleton. Radial transport along microtubules and lateral transport along the filaments of the actin cortex underneath the cell membrane are characteristic for cells with a centrosome. The interplay between the specific cytoskeleton organization and the motor performance realizes a spatially inhomogeneous intermittent search strategy. In order to analyze the efficiency of such intracellular search strategies we formulate a random velocity model with intermittent arrest states. We evaluate efficiency in terms of mean first passage times for three different, frequently encountered intracellular transport tasks: i) the narrow escape problem, which emerges during cargo transport to a synapse or other specific region of the cell membrane, ii) the reaction problem, which considers the binding time of two particles within the cell, and iii) the reaction-escape problem, which arises when cargo must be released at a synapse only after pairing with another particle. Our results indicate that cells are able to realize efficient search strategies for various intracellular transport tasks economically through a spatial cytoskeleton organization that involves only a narrow actin cortex rather than a cell body filled with randomly oriented actin filaments. Comment: 13 pages, 7 figures |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|