Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique
| Autor: | Pedro L. Alonso, Mauricio H. Rodríguez, Augusto Nhabomba, Alfredo Mayor, Carlota Dobaño, Maria N. Manaca, Chetan E. Chitnis, Quique Bassat, Pau Cisteró, Arnoldo Barbosa, Llorenç Quintó, John J. Aponte, Alfons Jiménez, Caterina Guinovart, Ruth Aguilar |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Erythrocytes Sulfadoxine medicine.medical_treatment Plasmodium falciparum Antibodies Protozoan Antigens Protozoan Enzyme-Linked Immunosorbent Assay Adaptive Immunity Chemoprevention Antibodies Exposure chemistry.chemical_compound Antimalarials Age Double-Blind Method parasitic diseases medicine Prevalence Humans Malaria Falciparum Acquired immunity Mozambique biology Incidence (epidemiology) Research Incidence Age Factors Infant medicine.disease biology.organism_classification Artemisinins Malaria Pyrimethamine Infectious Diseases chemistry Artesunate Child Preschool Immunology Chemoprophylaxis biology.protein Parasitology Female Antibody medicine.drug |
| Zdroj: | Malaria Journal |
| ISSN: | 1475-2875 0023-1452 |
| Popis: | The impact of the age of first Plasmodium falciparum infection on the rate of acquisition of immunity to malaria and on the immune correlates of protection has proven difficult to elucidate. A randomized, double-blind, placebo-controlled trial using monthly chemoprophylaxis with sulphadoxine-pyrimethamine plus artesunate was conducted to modify the age of first P. falciparum erythrocytic exposure in infancy and assess antibodies and malaria risk over two years. Participants (n = 349) were enrolled at birth to one of three groups: late exposure, early exposure and control group, and were followed up for malaria morbidity and immunological analyses at birth, 2.5, 5.5, 10.5, 15 and 24 months of age. Total IgG, IgG subclasses and IgM responses to MSP-119, AMA-1, and EBA-175 were measured by ELISA, and IgG against variant antigens on the surface of infected erythrocytes by flow cytometry. Factors affecting antibody responses in relation to chemoprophylaxis and malaria incidence were evaluated. Generally, antibody responses did not vary significantly between exposure groups except for levels of IgM to EBA-175, and seropositivity of IgG1 and IgG3 to MSP-119. Previous and current malaria infections were strongly associated with increased IgG against MSP-119, EBA-175 and AMA-1 (p |
| Databáze: | OpenAIRE |
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