Neonatal Sulfhemoglobinemia and Hemolytic Anemia Associated With Intestinal Morganella morganii
| Autor: | Kiera Murphy, C. Anthony Ryan, Paul W. O'Toole, Clodagh Ryan, Catherine Stanton, Eugene M. Dempsey, R. Paul Ross |
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| Rok vydání: | 2015 |
| Předmět: |
Hemolytic anemia
Anemia Hemolytic Anemia law.invention Microbiology Probiotic Feces Sulfhemoglobinemia law medicine Humans Microbiome Morganella morganii biology business.industry Enterobacteriaceae Infections Infant Newborn Hypoxia (medical) medicine.disease biology.organism_classification Gastrointestinal Microbiome Pediatrics Perinatology and Child Health Female medicine.symptom business Infant Premature |
| Zdroj: | Pediatrics. 136(6) |
| ISSN: | 1098-4275 |
| Popis: | Sulfhemoglobinemia is a rare disorder characterized by the presence of sulfhemoglobin in the blood. It is typically drug-induced and may cause hypoxia, end-organ damage, and death through oxygen deprivation. We present here a case of non–drug-induced sulfhemoglobinemia in a 7-day-old preterm infant complicated by hemolytic anemia. Microbiota compositional analysis of fecal samples to investigate the origin of hydrogen sulphide revealed the presence of Morganella morganii at a relative abundance of 38% of the total fecal microbiota at the time of diagnosis. M morganii was not detected in the fecal samples of 40 age-matched control preterm infants. M morganii is an opportunistic pathogen that can cause serious infection, particularly in immunocompromised hosts such as neonates. Strains of M morganii are capable of producing hydrogen sulphide, and virulence factors include the production of a diffusible α-hemolysin. The infant in this case survived intact through empirical oral and intravenous antibiotic therapy, probiotic administration, and red blood cell transfusions. This coincided with a reduction in the relative abundance of M morganii to 3%. Neonatologists should have a high index of suspicion for intestinal pathogens in cases of non–drug-induced sulfhemoglobinemia and consider empirical treatment of the intestinal microbiota in this potentially lethal condition. |
| Databáze: | OpenAIRE |
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