Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes

Autor: Hiroko Miyazaki, Akira Yoshida, Ayami Kajiwara, Kazunori Morita, Kazuko Nakagawa, Junji Saruwatari, Kentaro Oniki, Yuki Kawata, Ayana Kita, Hideaki Jinnouchi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Male
Longitudinal study
medicine.medical_specialty
Article Subject
Endocrinology
Diabetes and Metabolism
Renal function
Physiology
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Sex Factors
Japan
Internal medicine
Diabetes mellitus
Medicine
Humans
Diabetic Nephropathies
Longitudinal Studies
Renal Insufficiency
Aged
Retrospective Studies
Glycated Hemoglobin
Proteinuria
lcsh:RC648-665
Diabetic Retinopathy
business.industry
Retrospective cohort study
Diabetic retinopathy
Cholesterol
LDL
Middle Aged
medicine.disease
Diabetes Mellitus
Type 2
Metabolic control analysis
Multivariate Analysis
Linear Models
Female
medicine.symptom
business
Research Article
Glomerular Filtration Rate
Zdroj: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2016 (2016)
ISSN: 2314-6753
2314-6745
Popis: Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction.Methods. A clinic-based retrospective longitudinal study (follow-up duration:8.1±1.4years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses.Results. The mean annual eGFR change was-3.5±2.7%/year in females and-2.0±2.2%/year in males (P<0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline.Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.
Databáze: OpenAIRE
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