Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes
Autor: | Hiroko Miyazaki, Akira Yoshida, Ayami Kajiwara, Kazunori Morita, Kazuko Nakagawa, Junji Saruwatari, Kentaro Oniki, Yuki Kawata, Ayana Kita, Hideaki Jinnouchi |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Adult
Male Longitudinal study medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism Renal function Physiology 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology Sex Factors Japan Internal medicine Diabetes mellitus Medicine Humans Diabetic Nephropathies Longitudinal Studies Renal Insufficiency Aged Retrospective Studies Glycated Hemoglobin Proteinuria lcsh:RC648-665 Diabetic Retinopathy business.industry Retrospective cohort study Diabetic retinopathy Cholesterol LDL Middle Aged medicine.disease Diabetes Mellitus Type 2 Metabolic control analysis Multivariate Analysis Linear Models Female medicine.symptom business Research Article Glomerular Filtration Rate |
Zdroj: | Journal of Diabetes Research Journal of Diabetes Research, Vol 2016 (2016) |
ISSN: | 2314-6753 2314-6745 |
Popis: | Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction.Methods. A clinic-based retrospective longitudinal study (follow-up duration:8.1±1.4years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses.Results. The mean annual eGFR change was-3.5±2.7%/year in females and-2.0±2.2%/year in males (P<0.001). Baseline retinopathy and proteinuria were significantly associated with a larger eGFR decline, irrespective of sex, while HbA1c and LDL-cholesterol levels were significantly associated with an eGFR decline in females only. Interactive effects were observed between sex and the HbA1c, LDL-cholesterol, retinopathy, or proteinuria levels on the annual eGFR decline.Conclusions. The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females. |
Databáze: | OpenAIRE |
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