Comparative study of endralazine and hydralazine for the treatment of hypertension uncontrolled by a beta-blocker and diuretic
| Autor: | A. McCallum, K. Whaley, D. A. Duff, B. I. Chazan |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_treatment Adrenergic beta-Antagonists Patient response Essential hypertension Random Allocation Double-Blind Method Medicine Humans Diuretics Aged Random allocation Group study business.industry General Medicine Hydralazine Middle Aged medicine.disease Pyridazines Blood pressure Anesthesia Antibodies Antinuclear Hypertension Endralazine Drug Therapy Combination Female Diuretic business medicine.drug |
| Zdroj: | Current medical research and opinion. 10(3) |
| ISSN: | 0300-7995 |
| Popis: | Endralazine and hydralazine were compared in a randomized double-blind, parallel group study lasting 1 year in 30 patients with essential hypertension inadequately controlled by a beta-blocker and a diuretic. Dosage ranged from 10 mg to 30 mg endralazine per day and from 75 mg to 200 mg hydralazine per day according to patient response. The results showed that endralazine was at least as effective as hydralazine in reducing blood pressure. Patients' tolerance, assessed by drop-out rate, was significantly better (p less than 0.05) in the endralazine group. No cases were found of drug-induced lupus-like syndrome on endralazine as opposed to 2 cases with hydralazine. The dose of endralazine required much less adjustment than that of hydralazine. |
| Databáze: | OpenAIRE |
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