Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours
| Autor: | Lidia Hildebrand Pulz, Ricardo de Francisco Strefezzi, Camila Neri Barra, Karine Germano Cadrobbi, Adriana Tomoko Nishiya, Greice Cestari Huete, Silvia Regina Kleeb, José Luiz Catão-Dias, Thiago Henrique Moroni Vargas, José Guilherme Xavier |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasm General Veterinary NEOPLASIAS EM ANIMAL business.industry Galectin 3 Cancer Context (language use) medicine.disease Mast cell Dogs medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Galectin-3 Apoptosis Biomarkers Tumor medicine Animals Immunohistochemistry Dog Diseases Mast Cells business Survival analysis |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1588-2705 0236-6290 |
| DOI: | 10.1556/004.2021.00019 |
| Popis: | Mast cell tumour (MCT) is the most frequent skin neoplasm in dogs. These tumours are characterised by variable behaviour and clinical presentation that make prognosis an important and challenging task in the veterinary practice. Galectin-3 (Gal-3) is known to influence several biological processes that are important in the cancer context and has been described as a prognostic marker for several human cancers. The aim of the present work was to characterise Gal-3 immunolabelling in canine cutaneous MCTs and to investigate its value as a prognostic marker for the disease. Thirty-four random cases of canine cutaneous MCT that were surgically treated with wide margins were included in this study. Gal-3 expression was evaluated using immunohistochemistry and the results were compared with the expression of apoptosis-related proteins, Ki67 index, histopathological grades, mortality due to the disease and post-surgical survival. The majority of the MCTs (65.8%) were positive for Gal-3. Gal-3 immunolabelling was variable among the samples (2.7%–86.8% of the neoplastic cells). The protein was located in the cytoplasm or in the cytoplasm and the nucleus. Gal-3 positivity was correlated with BCL2 expression (P < 0.001; r = 0.604), but not with Ki67 and BAX. No significant differences were detected between histological grades or in the survival analysis. Gal-3 expression correlates with BCL2 expression in MCTs. Although an efficient marker for several human neoplasms, the results presented herein suggest that Gal-3 immunolabelling is not an independent prognostic indicator for this disease. |
| Databáze: | OpenAIRE |
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