The Role of Physical Exercise and Omega-3 Fatty Acids in Depressive Illness in the Elderly
| Autor: | Stefano Farioli-Vecchioli, Stefano Sacchetti, Nicolis V. di Robilant, Debora Cutuli |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty physical activity Poison control Physical exercise Disease Article late-life depression 03 medical and health sciences 0302 clinical medicine Fatty Acids Omega-3 medicine Animals Humans Pharmacology (medical) Depression Diet Exercise Late-Life Depression Mood disorders Omega-3 fatty acids Physical activity Psychiatry Depression (differential diagnoses) Aged Pharmacology Depressive Disorder exercise omega-3 fatty acids business.industry Brain General Medicine Late life depression medicine.disease Mental illness mood disorders Mental health Exercise Therapy Psychiatry and Mental health 030104 developmental biology Neurology depression Neurology (clinical) Medical emergency diet business aging 030217 neurology & neurosurgery |
| Zdroj: | Current neuropharmacology (2017). doi:10.2174/1570159X15666170912113852 info:cnr-pdr/source/autori:Farioli-Vecchioli, Stefano; Sacchetti, Stefano; di Robilant, Vittoria Nicolis; Cutuli, Debora/titolo:Role of physical exercise and omega-3 fatty acids on depressive illness in the elderly./doi:10.2174%2F1570159X15666170912113852/rivista:Current neuropharmacology/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume Current Neuropharmacology |
| ISSN: | 1570-159X |
| DOI: | 10.2174/1570159x15666170912113852 |
| Popis: | Background: In adulthood, depression is the most common type of mental illness and will be the second leading cause of disease by 2020. Major depression dramatically affects the function of the central nervous system and degrades the quality of life, especially in old age. Several mechanisms underlie the pathophysiology of depressive illness, since it has a multifactorial etiology. Human and an-imal studies have demonstrated that depression is mainly associated with imbalances in neurotransmitters and neurotrophins, hypothalamic-pituitary-adrenal axis alterations, brain volume changes, neurogenesis dysfunction, and dysregulation of in-flammatory pathways. Also the gut microbiota may influence mental health outcomes. Although depression is not a consequence of normal aging, depressive disorders are common in later life, even if often undi-agnosed or mis-diagnosed in old age. When untreated, depression reduces life expectancy, worsens medical illnesses, en-hances health care costs and is the primary cause of suicide among older people. To date, the underpinnings of depression in the elderly are still to be understood, and the pharmacological treatment is the most commonly used therapy. Objective: Since a sedentary lifestyle and poor eating habits have recently emerged as crucial contributors to the genesis and course of depression, in the present review, we have focused on the effects of physical activity and omega-3 fatty acids on depressive illness in the elderly. Results: A growing literature indicates that both exercise and dietary interventions can promote mental health throughout one’s lifespan. Conclusion: There thus emerges the awareness that an active lifestyle and a balanced diet may constitute valid low-cost pre-vention strategies to counteract depressive illness in the elderly. |
| Databáze: | OpenAIRE |
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