| Autor: |
Compton, Zachary, Harris, Valerie, Mellon, Walker, Rupp, Shawn, Mallo, Diego, Kapsetaki, Stefania E., Wilmot, Mallory, Kennington, Ryan, Noble, Kathleen, Baciu, Cristina, Ramirez, Lucia, Peraza, Ashley, Martins, Brian, Sudhakar, Sushil, Aksoy, Selin, Furukawa, Gabriella, Vincze, Orsolya, Giraudeau, Mathieu, Duke, Elizabeth G., Spiro, Simon, Flach, Edmund, Davidson, Hannah, Zehnder, Ashley, Graham, Trevor A., Troan, Brigid, Harrison, Tara M., Tollis, Marc, Schiffman, Joshua D., Aktipis, Athena, Abegglen, Lisa M., Maley, Carlo C., Boddy, Amy M. |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
bioRxiv |
| Popis: |
Cancer is pervasive across multicellular species. Are there any patterns that can explain differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades (amphibians, sauropsids and mammals) we found that neoplasia and malignancy prevalence increases with adult weight and decreases with gestation time, contrary to Peto’s Paradox. Evolution of cancer susceptibility appears to have undergone sudden shifts followed by stabilizing selection. Outliers for neoplasia prevalence include the common porpoise ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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