Reduced forearm reactive hyperaemia in normoalbuminuric subjects with Type 1 diabetes and retinopathy
| Autor: | Ken Shaw, Gerald F. Watts, Michael H. Cummings, J. Cansfield, B. Turner, U. Weis, D. R. Meeking, J. Gibney |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Hyperemia Hyperaemia Sex Factors Endocrinology Forearm Diabetes mellitus Internal medicine Internal Medicine medicine Albuminuria Humans Endothelial dysfunction Type 1 diabetes Diabetic Retinopathy business.industry Age Factors Diabetic retinopathy Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 medicine.anatomical_structure Cardiology Female Microalbuminuria medicine.symptom business Retinopathy |
| Zdroj: | Diabetic Medicine. 21:931-935 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.2004.01203.x |
| Popis: | Aim To determine whether the forearm vasodilatory response to reactive hyperaemia (RH) is reduced in normoalbuminuric subjects with Type 1 diabetes mellitus and retinopathy compared with subjects with no retinopathy. Methods Forearm RH, an indicator of endothelial function, was measured, using strain-gauge plethysmography, in 39 normoalbuminuric subjects (22 with retinopathy) with long-standing Type 1 diabetes mellitus. Results were evaluated in relation to conventional risk factors for atherosclerosis, and C-reactive protein (CRP), which we have recently determined to be an independent correlate of forearm RH. Results Forearm RH was decreased in subjects with retinopathy compared with those with no retinopathy (219 ± 182 vs. 473 ± 355, P |
| Databáze: | OpenAIRE |
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