Antidiabetic Effects of a Short Peptide of Potato Protein Hydrolysate in STZ-Induced Diabetic Mice
| Autor: | Wan Teng Lin, Shibu Marthandam Asokan, Wei-Ting Su, Ting Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Protein Hydrolysates alcalase medicine.medical_treatment chemistry.chemical_compound 0302 clinical medicine Insulin Subtilisins Acarbose Plant Proteins Mice Inbred ICR Nutrition and Dietetics Lipids β-cell 030220 oncology & carcinogenesis diabetes mellitus lcsh:Nutrition. Foods and food supply Oligopeptides medicine.drug APPH medicine.medical_specialty Blood sugar lcsh:TX341-641 Hydrolysate Streptozocin Article Diabetes Mellitus Experimental 03 medical and health sciences Islets of Langerhans Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Solanum tuberosum Glycated Hemoglobin Cholesterol Streptozotocin medicine.disease 030104 developmental biology Endocrinology chemistry Blood chemistry hyperglycemia bioactive peptides Biomarkers Food Science |
| Zdroj: | Nutrients Volume 11 Issue 4 Nutrients, Vol 11, Iss 4, p 779 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11040779 |
| Popis: | Alcalase- generated potato protein hydrolysate (APPH) is a potential bioactive peptide against diabetes mellitus (DM) and DM-associated secondary effects in animal models. The aim of the present study was to find the efficiency of a deca-peptide DIKTNKPVIF (DF) from APPH against DM. Six-week-old male ICR mice were divided into the following groups: Control, Control+DF (received 50 mg/kg DF), streptozotocin (STZ)-induced DM group, DM+Acarbose group (20 mg/kg of acarbose), DM+DF-L (25 mg/kg of DF), DM+DF-H (50 mg/kg of DF), and DM+APPH (50 mg/kg of APPH). Comparable to APPH, treatment with DF effectively regulated blood glucose level and also controlled plasma total glycerol (TG), total cholesterol (TC), insulin, and HbA1c levels in DM animals. DF treatment also showed evidence of ameliorating DM-associated damages in the pancreatic islets and in the liver, heart, and kidney tissues. Therefore, the results demonstrate that the short synthetic peptide-DF may effectively provide protection against DM-associated damages. |
| Databáze: | OpenAIRE |
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