In situ synthesis and characterization of hydroxyapatite/natural rubber composites for biomedical applications
| Autor: | L.A. dos Santos, Teo Atz Dick |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Composite number Nucleation Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Bone and Bones Biomaterials Adsorption Natural rubber Biomimetic synthesis Materials Testing Humans Solubility Composite material 021001 nanoscience & nanotechnology 0104 chemical sciences Durapatite Mechanics of Materials visual_art visual_art.visual_art_medium Crystallite Rubber 0210 nano-technology Dispersion (chemistry) |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 77 |
| ISSN: | 1873-0191 |
| Popis: | In this work, a biomimetic synthesis reaction for the production of hydroxyapatite (HA)/natural rubber (NR) composites is presented. HA was synthesized in the presence of solubilized NR in tetrahydrofuran (THF), which permits that negatively charged domains in proteins and lipids in NR work as nucleation sites for hydroxyapatite. The mechanical and physicochemical properties of composites containing 10, 20 and 30wt% HA were studied. NR influenced HA crystallite morphology, shape and size and was able to disperse the HA particles in THF. The dispersion of HA in the composites promoted the enhancement of mechanical properties and loss of solubility of composites, which is believed to be macroscopic manifestations of the physical adsorption of NR to HA particles, known as the bound rubber phenomenon. Preliminary cell studies indicated that HepG2 cells presented viabilities ranging from 71.6 to 91.3%, with cell proliferation positively influenced by HA content at shorter culture times. The good dispersion of HA in the composites is expected to improve NR bioactivity and direct its use towards bone applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect