Paradoxical changes in lumen size during progression and regression of carotid atherosclerosis
| Autor: | Vikas K Rathi, George Angheloiu, Geetha Rayarao, David R Neff, Saundra B Grant, Ronald B Williams, June Yamrozik, Mark Doyle, Sobhan Kodali, Robert W Biederman |
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| Jazyk: | angličtina |
| Předmět: |
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty Pathology Statin medicine.drug_class Asymptomatic Text mining Ezetimibe In vivo Internal medicine medicine Radiology Nuclear Medicine and imaging cardiovascular diseases Angiology Medicine(all) Radiological and Ultrasound Technology business.industry medicine.disease Stenosis lcsh:RC666-701 Simvastatin Cardiology Oral Presentation lipids (amino acids peptides and proteins) medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Magnetic Resonance Journal of Cardiovascular Magnetic Resonance, Vol 14, Iss Suppl 1, p O43 (2012) |
| ISSN: | 1532-429X |
| DOI: | 10.1186/1532-429x-14-s1-o43 |
| Popis: | Summary Atherosclerotic changes regarding the lipid pool and frbrous cap are related to the lumen and show countgerintuitive changes; a discourse on Glagov’s Hypothesis. Background Relative changes in arterial lumen size during progression and regression of atherosclerosis particularly in response to lipid modulating therapy are largely unknown. This study was designed to investigate the effects of statin therapy on human carotid atherosclerotic lesions as measured by high-resolution Cardiac Magnetic Resonance (CMR). Methods Via CMR (1.5T GE, WI), 35 carotid arteries of 18 asymptomatic, ‘statin naive’ patients with maximum carotid stenosis >50% (mean 64±21), were imaged at baseline and following 12 months of randomized, blinded statin therapy (simvastatin 40mg or Vytorin (Ezetimibe 10mg/ simvastatin 40mg)). The effects of statins on these lesions were evaluated as changes in carotid outer wall area (OWA), lumen area (LuA), vessel wall area (VWA), lipid area (LpA) and lipid percentage (Lp%). The percentage of stenosis of each slice was determined in reference to a normal or near normal sl. Results A total of 707-2mm slices of interpretable quality were available representing 39 in vivo plaques. Among these as followed over time, 378 (53.5%) demonstrated progression while 329 (46.5%) showed regression. Among ‘Progressors’, OWA, VWA, Lp% and LuA increased (P< .001 for OWA, VWA and Lp% and 0.14 for LuA), while among ‘Regressors’, all the above parameters decreased significantly (P |
| Databáze: | OpenAIRE |
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