Reply to Slominski et al.: UVB irradiation induces proenkephalin(+) regulatory T cells with a wound-healing function
| Autor: | Sayuri Yamazaki, Ryuta Uraki, Anthony J. Bonito, Maiko Watanabe, Kiyoshi Minohara, Makoto Tsuiji, Masaki Imai, Hiroaki Shime, Naganari Ohkura, Takuma Matoba, Hidehiro Fukuyama, Yoshiaki Yasumizu, Akimichi Morita, Mizuyu Odanaka, Shimon Sakaguchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Multidisciplinary Letter integumentary system Chemistry Neuropeptide FOXP3 Enkephalins Molecular biology T-Lymphocytes Regulatory Proenkephalin 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system Homeostasis Uvb irradiation IL-2 receptor Protein Precursors Wound healing Function (biology) 030215 immunology Skin |
| Zdroj: | Proc Natl Acad Sci U S A |
| Popis: | Foxp3+CD25+CD4+ regulatory T (Treg) cells constitute about 10% of peripheral CD4+ T cells and suppress a variety of immune responses in mice and humans (1). Our recent report (2) shows that proenkephalin (PENK)-expressing Treg cells expanded by ultraviolet B (UVB) exposure promoted wound healing. The Letter from Slominski et al. (3) points out that skin-resident cells produce enkephalins and other neuropeptides and that skin neuroendocrine activity exerted by keratinocytes, fibroblasts, and melanocytes was detected early after UVB irradiation within a day (3⇓⇓–6), although they did not address possible roles of PENK produced by skin T cells (3⇓⇓– … [↵][1]2To whom correspondence may be addressed. Email: yamazas{at}med.nagoya-cu.ac.jp. [1]: #xref-corresp-1-1 |
| Databáze: | OpenAIRE |
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