The Role of Peyer's Patches in the Age-Related Incidence of Crohn's Disease
| Autor: | Benjamin J. Freda, H. J. Van Kruiningen, L. M. Ganley |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Concordance Disease Gastroenterology Peyer's Patches Crohn Disease Ileum Internal medicine Age related medicine Humans Child Aged Crohn's disease Crohn disease business.industry Incidence (epidemiology) Age Factors Infant Middle Aged medicine.disease Peyer Patch Child Preschool Immunology Female business |
| Zdroj: | Journal of Clinical Gastroenterology. 25:470-475 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-199709000-00017 |
| Popis: | Recently researchers have suggested that clinical subsets of Crohn's disease occur, which are variously described as inflammatory, fibrostenotic, and fistulizing. In addition, it has been observed that within families with multiple cases, often there is concordance of the site and type of disease. The lesions of Crohn's disease occur in segments that suggest that distribution of Peyer's patches. When the age-related incidence of Crohn's disease was plotted for all countries from which such data were available, the peaks of greatest case frequency occurred at ages 15 to 25 years and paralleled a similar peak representing the number of Peyer's patches as a function of age. This correlation suggests that Crohn's disease may develop as an inflammatory process specifically targeting these important lymphoid structures. Similar peaks of activity in the adolescent to early adult years occur for appendicitis and tonsillitis. |
| Databáze: | OpenAIRE |
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