Modulation effect of vaginal mucosal microflora and susceptibility to Neisseria gonorrhoeae infections: a systematic review and meta-analysis
Autor: | Jingxin Zeng, Xuelian Zhong, Ridong Yang, Xibao Zhang, Quan Luo, Weiyu Liu, Hui-Lan Zhu, Wanping He |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Funnel plot Modulation effect Gonorrhea Gastroenterology 03 medical and health sciences 0302 clinical medicine RNA Ribosomal 16S Internal medicine Humans Medicine Mucous Membrane 030219 obstetrics & reproductive medicine biology business.industry Obstetrics and Gynecology General Medicine Publication bias medicine.disease biology.organism_classification Neisseria gonorrhoeae 030220 oncology & carcinogenesis Meta-analysis Vagina Female Nugent score Neisseria business Clue cell |
Zdroj: | Archives of Gynecology and Obstetrics. 300:261-267 |
ISSN: | 1432-0711 0932-0067 |
Popis: | The vaginal microbiota may modulate susceptibility to Neisseria gonorrhea (NG) infections. The objective of this meta-analysis was to evaluate the association between these NG infections and the vaginal microbiota. A systematic review and meta-analysis was conducted to investigate the correlation of vaginal microbiota and NG risk. Primary sources of the reviewed studies were from inception through December 2018. Vaginal mucosa microflora were dichotomized into high-Lactobacillus vaginal microbiota and low-Lactobacillus vaginal microbiota (LL-VMB), using either Nugent score, Amsel’s criteria, presence of clue cells or 16S rRNA gene sequencing. A total of 8 studies qualified for inclusion in this meta-analysis. LL-VMB could be regarded as worse prognostic factor, and the pooled OR was 1.33 (95% CI 1.02, 1.73; P = 0.04, I2 = 44%). LL-VMB was associated with a significantly higher susceptibility of NG. Trend for the sensitive analysis was consistence with the primary outcome. Significant publication bias was not detected by the funnel plot. In conclusion, the systematic review and meta-analysis has demonstrated that LL-VMB was significantly associated with a high NG susceptibility. |
Databáze: | OpenAIRE |
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