Diagnostic Value of the Survivin Autoantibody in Four Types of Malignancies
| Autor: | Baosheng Sun, Yongli Jiang, Shilong Sun, Linlin Liu, Aifu Wang, Yuting Xiu, Mingmei Huangfu, Ying Liu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Survivin Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Inhibitor of Apoptosis Proteins 03 medical and health sciences 0302 clinical medicine Antigen Neoplasms Biomarkers Tumor Humans Medicine Secretion Genetics (clinical) Aged Autoantibodies business.industry Autoantibody General Medicine Middle Aged Case-Control Studies 030220 oncology & carcinogenesis Cancer research 030211 gastroenterology & hepatology business Value (mathematics) |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 22:384-389 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2017.0278 |
| Popis: | Tumor-associated antigen overexpression, which has been reported in many types of cancers, may trigger autoantibody secretion. The present study was designed to test whether levels of circulating autoantibodies to survivin protein-derived antigens is altered in liver, esophageal, breast, and lung cancers.Patients with liver (144), esophageal (159), breast (124), and lung cancers (267), and healthy volunteers (362) were recruited for the study, and serum samples were collected for ELISA autoantibody analysis.Compared with the control group, survivin autoantibody levels were significantly higher in serum from patients with breast cancer and lung cancer, but were significantly lower in serum from patients with liver cancer (p 0.05). In stage I and II lung cancer, the best-fit areas under the receiver operating characteristic curve was 0.731 (standard error [SE] = 0.023; 95% confidence interval [CI] 0.687-0.776) and the sensitivity, with 90% specificity, was 23.7%.Analysis across four types of malignancies revealed that the survivin autoantibody had good specificity and sensitivity in lung cancer. Circulating autoantibodies to survivin could be a potential biomarker for the early lung cancer diagnosis. |
| Databáze: | OpenAIRE |
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