Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus�scrofa is positively modulated by stem cells
Autor: | Jiri Červeň, Jan Oppelt, M Peteja, Petr Pečinka, Martin Bartas, Petr Vávra, Pavel Zonča, Václav Brázda, Václav Procházka |
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Rok vydání: | 2018 |
Předmět: |
Cancer Research
Pathology medicine.medical_specialty medicine.medical_treatment Sus scrofa Cell Inflammation associating liver partition and portal vein ligation for staged hepatectomy transcriptome sequencing Biology 03 medical and health sciences 0302 clinical medicine stem cells Fibrosis medicine liver regeneration Oncogene Articles Cell cycle medicine.disease Liver regeneration medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology medicine.symptom Hepatectomy Stem cell |
Zdroj: | Oncology Letters |
ISSN: | 1792-1082 1792-1074 |
Popis: | This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation). In the group that did receive application of stem cells, no significantly differentially expressed genes were found, indicating a properly regenerated liver remnant. The present study therefore demonstrated, to the best of our knowledge for the first time, the positive effect of stem cells application in the liver regeneration process during ALPPS procedure in the pig model. |
Databáze: | OpenAIRE |
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