One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation

Autor:	Jianru Shi, Wangde Dai, Jesus Chavez, Juan Carreno, Lifu Zhao, Michael T. Kleinman, Rebecca J. Arechavala, Irene Hasen, Amanda Ting, Bishop Bliss, Jessica E. Monterrosa Mena, Robert A. Kloner
Rok vydání:	2022
Předmět:	History Lung inflammation Tobacco Smoke and Health Polymers and Plastics Vaping Industrial and Manufacturing Engineering E-cigarette Rare Diseases Tobacco Respiratory Burnt coil Business and International Management Cardiology and Cardiovascular Medicine Lung Acute Respiratory Distress Syndrome
Zdroj:	Cardiology research, vol 13, iss 6
ISSN:	1923-2837 1923-2829
DOI:	10.14740/cr1425
Popis:	BackgroundElectronic cigarettes (eC) may not be entirely benign. There is a lack of data on the effect of a single acute exposure of eC vapor using various heating sources and power settings upon lung injury. The purpose of this study was to determine if an acute exposure with eC vapor heated with different heating elements and power levels induced inflammatory changes in the lungs and heart.MethodsRats were exposed to pure air or received a single, 4-h exposure to eC vapor. The devices used either a stainless steel (SS) or nichrome (NC) heating element randomized to a low or high atomization power (45 versus 70 W). Rats were euthanized within 48 h of exposure.ResultsThe eC groups showed accumulation of inflammatory cells in bronchial lumen, near the pleura, and within the alveolar spaces. The numbers of inflammatory cells per field in the lung parenchyma were significantly greater in the rats exposed to eC groups vs. the air group. There were significantly higher inflammatory gene expression changes in the lungs of animals assigned to 70 W power. We observed that eC vapor generated using burnt coils were toxic and could cause acute respiratory distress and myocarditis.ConclusionIn conclusion, one 4-h exposure to eC vapor, in the absence of vitamin E oil or nicotine, significantly increased lung inflammation. Effects were seen after exposures to vapor generated using SS and NC heating elements at either high or low power. Vapor from devices with burnt coils can negatively affect the heart and lung.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3efb3f4f39a4a6fa2dc37a9bc73b98 https://doi.org/10.14740/cr1425 Zobrazit plný text záznamu