Gene drive to reduce malaria transmission in sub-Saharan Africa
| Autor: | Austin Burt, Andrea Crisanti, Jonathan K. Kayondo, Mamadou B. Coulibaly, Abdoulaye Diabaté |
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| Přispěvatelé: | The Royal Society, Grand Challenges in Global Health, Bill & Melinda Gates Foundation, Silicon Valley Community Foundation |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Information Systems and Management Sub saharan Strategy and Management vector control VECTOR 03 medical and health sciences Malaria transmission Management of Technology and Innovation Environmental health parasitic diseases medicine POPULATION ELIMINATION SUPPRESSION gene drive Malaria History & Philosophy Of Science HOMING ENDONUCLEASE GENES Arts & Humanities Gene drive medicine.disease ANOPHELES-GAMBIAE MOSQUITO DROSOPHILA 030104 developmental biology Geography REQUIREMENTS SYSTEM |
| Zdroj: | S80 S66 |
| ISSN: | 2329-9037 2329-9460 |
| DOI: | 10.1080/23299460.2017.1419410 |
| Popis: | Despite impressive progress, malaria continues to impose a substantial burden of mortality and morbidity, particularly in sub-Saharan Africa, and new tools will be needed to achieve elimination. Gene drive is a natural process by which some genes are inherited at a greater-than-Mendelian rate and can spread through a population even if they cause harm to the organisms carrying them. Many different synthetic gene drive systems have been proposed to suppress the number of mosquitoes and/or reduce vector competence. As with any control measure, due attention should be paid to the possible evolution of resistance. No gene drive construct has yet been reported that is ‘field-ready’ for release, and when such constructs are developed, they should be assessed on a case-by-case basis. Gene drive approaches to vector control promise to have a number of key features that motivate their continued development, and scrutiny, by all concerned. |
| Databáze: | OpenAIRE |
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