Effects of Resistance Training on Immunoinflammatory Response, TNF-Alpha Gene Expression, and Body Composition in Elderly Women
Autor: | Luís Ângelo Macêdo Santiago, Aruanã Joaquim Matheus Rodrigues Pinheiro, Janaina de Oliveira Brito Monzani, Guilherme Borges Pereira, Lídio Gonçalves Lima Neto, Francisco Navarro, Cristiano T. Mostarda, Richard Diego Leite, Wandson Rodrigues Sousa |
---|---|
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Article Subject business.industry Antagonist Resistance training 030229 sport sciences lcsh:Geriatrics Immune modulation Training methods Gastroenterology law.invention lcsh:RC952-954.6 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Statistical significance Gene expression medicine Tumor necrosis factor alpha Geriatrics and Gerontology business 030217 neurology & neurosurgery Research Article |
Zdroj: | Journal of Aging Research, Vol 2018 (2018) Journal of Aging Research |
ISSN: | 2090-2212 2090-2204 |
Popis: | The aim of this study was to determine the effects of resistance training on the immunologic response, body composition, tumor necrosis factor-alpha (TNF-alpha) gene expression obtained from blood leukocytes, and the cytokines interleukin-6, TNF-alpha, and C-reactive protein (CRP), in the elderly women (mean age 63 ± 2 y). A randomized controlled trial was performed using a bi-set training method for eight weeks in nineteen elderly women. Peripheral blood samples were collected by puncture in pretraining (Pre) and posttraining (Post) moments. In the resistance training group, there was a statistically significant decrease from 38.43 ± 9.48 pg/mL to 11.76 ± 5.19 pg/mL (p=0.01) in the serum levels of interleukin-6. Considering serum levels of TNF-alpha, there was a statistically significant difference, comparing the resistance training group at Pre (66.27 ± 10.31 pg/mL) and Post (37.85 ± 9.05 pg/mL) moments (p=0.01). In molecular analysis of TNF-alpha gene expression, there was a statistically significant decrease (p=0.007) between Pre (0.010 ± 0.01 ng/ml) and Post (0.0002 ± 0.0001 ng/ml) moments. Among CRP data, in the resistance training group, there was a statistically significant reduction, between Pre (2.04 ± 0.32 mg/L) and Post (0.90 ± 0.22 mg/L) moments (p=0.001). In the Control group, there was no statistical significance between these two moments. Therefore, the resistance training demonstrated changes in the TNF-alpha gene expression in elderly women, as well as decreased serum levels of interleukin-6, TNF-alpha, and CRP. Such conditions may be related to immune modulation and anti-inflammatory effects, since resistance training releases cytokines, especially interleukin-6, which acts as a TNF-alpha antagonist during exercise. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |