Spirulina platensis Improves Mitochondrial Function Impaired by Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin Sensitivity in Equine Metabolic Syndrome (EMS) Horses
Autor: | Katarzyna Kornicka, Krzysztof Marycz, Agnieszka Śmieszek, Daria Nawrocka |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Pharmaceutical Science Adipose tissue Spirulina platensis Inflammation Systemic inflammation medicine.disease_cause Article 03 medical and health sciences Insulin resistance Internal medicine insulin resistance Drug Discovery medicine Spirulina Animals Horses Obesity Intestinal Mucosa Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 equine metabolic syndrome mesenchymal stromal cells intestinal epithelial cells oxidative stress inflammation Spirulina (genus) Metabolic Syndrome biology Mesenchymal stem cell Epithelial Cells Mesenchymal Stem Cells medicine.disease biology.organism_classification Mitochondria Intestines Oxidative Stress 030104 developmental biology Endocrinology Equine metabolic syndrome lcsh:Biology (General) Adipose Tissue Immunology medicine.symptom Oxidative stress |
Zdroj: | Marine Drugs; Volume 15; Issue 8; Pages: 237 Marine Drugs Marine Drugs, Vol 15, Iss 8, p 237 (2017) |
ISSN: | 1660-3397 |
DOI: | 10.3390/md15080237 |
Popis: | Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)-the first-line cells exposed to dietary compounds. In the conducted research, we showed that in vitro application of Spirulina platensis contributes to the restoration of ASCs' and IECs' morphology and function through the reduction of cellular oxidative stress and inflammation. Enhanced viability, suppressed senescence, and improved proliferation of ASCs and IECs isolated from metabolic syndrome-affected individuals were evident following exposition to Spirulina. A protective effect of the investigated extract against mitochondrial dysfunction and degeneration was also observed. Moreover, our data demonstrate that Spirulina extract effectively suppressed LPS-induced inflammatory responses in macrophages. In vivo studies showed that horses fed with a diet based on Spirulina platensis supplementation lost weight and their insulin sensitivity improved. Thus, our results indicate the engagement of Spirulina platensis nourishing as an interesting alternative approach for supporting the conventional treatment of equine metabolic syndrome. |
Databáze: | OpenAIRE |
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