Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients

Autor: Fois, Adrien, Boucher-Lafleur, Anne-Marie, Thompson Legault, Julie, Renaud, Christian, Morin, Charles, Des Rosiers, Christine, Coderre, Lise, Laprise, Catherine, Lesage, Sylvie, LSFC Consortium
Přispěvatelé: Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
RNA viruses
Male
Viral Diseases
Physiology
Respiratory chain
medicine.disease_cause
Pathology and Laboratory Medicine
Antibodies
Viral
Biochemistry
Rubella vaccine
0302 clinical medicine
Immunogenicity
Vaccine
Immune Physiology
Child
education.field_of_study
Vaccines
Multidisciplinary
Immune System Proteins
biology
Vaccination
Quebec
Neoplasm Proteins
MMR vaccine
Medical Microbiology
Viral Pathogens
Viruses
Medicine
Infectious diseases
Female
Antibody
Pathogens
Leigh Disease
medicine.drug
Research Article
Medical conditions
Adult
Adolescent
Science
Population
Immunology
Measles Virus
Mumps virus
Rubella
Microbiology
Antibodies
Mumps Virus
03 medical and health sciences
Immune system
Virology
Infectious disease control
medicine
Humans
education
Microbial Pathogens
Mumps
Medicine and health sciences
Biology and life sciences
business.industry
Viral vaccines
Organisms
Proteins
medicine.disease
030104 developmental biology
Paramyxoviruses
biology.protein
business
030217 neurology & neurosurgery
Measles-Mumps-Rubella Vaccine
Measles
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0239860 (2020)
ISSN: 1932-6203
Popis: Leigh Syndrome French Canadian (LSFC) is a rare autosomal recessive metabolic disorder characterized by severe lactic acidosis crises and early mortality. LSFC patients carry mutations in the Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) gene, which lead to defects in the respiratory chain complexes and mitochondrial dysfunction. Mitochondrial respiration modulates cellular metabolic activity, which impacts many cell types including the differentiation and function of immune cells. Hence, we postulated that, in addition to neurological and metabolic disorders, LSFC patients may show impaired immune activity. To gain insight into the quality of the immune response in LSFC patients, we examined the response to the measles, mumps and rubella (MMR) vaccine by measuring antibody titers to MMR in the plasma. In a cohort of eight LSFC patients, the response to the MMR vaccine was variable, with some individuals showing antibodies to all three viruses, while others had antibodies to two or fewer viruses. These results suggest that the mutations in the LRPPRC gene present in LSFC patients may affect the immune response to vaccines. Monitoring vaccine response in this fragile population should be considered to ensure full protection against pathogens.
Databáze: OpenAIRE
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