Humoral responses to the measles, mumps and rubella vaccine are impaired in Leigh Syndrome French Canadian patients
Autor: | Fois, Adrien, Boucher-Lafleur, Anne-Marie, Thompson Legault, Julie, Renaud, Christian, Morin, Charles, Des Rosiers, Christine, Coderre, Lise, Laprise, Catherine, Lesage, Sylvie, LSFC Consortium |
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Přispěvatelé: | Université de Montréal. Faculté de médecine. Département de microbiologie, infectiologie et immunologie |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
RNA viruses Male Viral Diseases Physiology Respiratory chain medicine.disease_cause Pathology and Laboratory Medicine Antibodies Viral Biochemistry Rubella vaccine 0302 clinical medicine Immunogenicity Vaccine Immune Physiology Child education.field_of_study Vaccines Multidisciplinary Immune System Proteins biology Vaccination Quebec Neoplasm Proteins MMR vaccine Medical Microbiology Viral Pathogens Viruses Medicine Infectious diseases Female Antibody Pathogens Leigh Disease medicine.drug Research Article Medical conditions Adult Adolescent Science Population Immunology Measles Virus Mumps virus Rubella Microbiology Antibodies Mumps Virus 03 medical and health sciences Immune system Virology Infectious disease control medicine Humans education Microbial Pathogens Mumps Medicine and health sciences Biology and life sciences business.industry Viral vaccines Organisms Proteins medicine.disease 030104 developmental biology Paramyxoviruses biology.protein business 030217 neurology & neurosurgery Measles-Mumps-Rubella Vaccine Measles |
Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 10, p e0239860 (2020) |
ISSN: | 1932-6203 |
Popis: | Leigh Syndrome French Canadian (LSFC) is a rare autosomal recessive metabolic disorder characterized by severe lactic acidosis crises and early mortality. LSFC patients carry mutations in the Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) gene, which lead to defects in the respiratory chain complexes and mitochondrial dysfunction. Mitochondrial respiration modulates cellular metabolic activity, which impacts many cell types including the differentiation and function of immune cells. Hence, we postulated that, in addition to neurological and metabolic disorders, LSFC patients may show impaired immune activity. To gain insight into the quality of the immune response in LSFC patients, we examined the response to the measles, mumps and rubella (MMR) vaccine by measuring antibody titers to MMR in the plasma. In a cohort of eight LSFC patients, the response to the MMR vaccine was variable, with some individuals showing antibodies to all three viruses, while others had antibodies to two or fewer viruses. These results suggest that the mutations in the LRPPRC gene present in LSFC patients may affect the immune response to vaccines. Monitoring vaccine response in this fragile population should be considered to ensure full protection against pathogens. |
Databáze: | OpenAIRE |
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