Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions
| Autor: | Paul A. Marks |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Biophysics
Neovascularization Physiologic Antineoplastic Agents Biochemistry Article Histone Deacetylases Structure-Activity Relationship Cell Movement Structural Biology Genetics Animals Humans Molecular Biology Cell Proliferation Regulation of gene expression Histone deacetylase 5 Cell Death biology HDAC11 Cell growth Cell migration Cell biology Histone Deacetylase Inhibitors Histone Gene Expression Regulation biology.protein Histone deacetylase Chemical genetics |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1799:717-725 |
| ISSN: | 1874-9399 |
| DOI: | 10.1016/j.bbagrm.2010.05.008 |
| Popis: | There are eleven zinc dependent histone deacetylases (HDAC) in humans which have histones and many non-histone substrates. The substrates of these enzymes include proteins that have a role in regulation of gene expression, cell proliferation, cell migration, cell death, immune pathways and angiogenesis. Inhibitors of HDACs (HDACi) have been developed which alter the structure and function of these proteins, causing molecular and cellular changes that induce transformed cell death. The HDACi are being developed as anti-cancer drugs and have therapeutic potential for many non-oncologic diseases. |
| Databáze: | OpenAIRE |
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