Impact of different pH thresholds for 24-hour dual probe pH monitoring in patients with suspected laryngopharyngeal reflux
| Autor: | Wolfgang Issing, O Reichel |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Esophageal pH Monitoring Ph monitoring Gastroenterology Laryngeal Diseases Laryngopharyngeal reflux Pepsin Reference Values Internal medicine medicine Humans In patient Prospective Studies Prospective cohort study medicine.diagnostic_test biology business.industry Esophageal disease Reflux Gastric Acidity Determination Pharyngeal Diseases General Medicine Hydrogen-Ion Concentration Middle Aged medicine.disease Pepsin A Otorhinolaryngology Gastroesophageal Reflux biology.protein Female Larynx Esophageal pH monitoring business |
| Zdroj: | The Journal of Laryngology & Otology. 122:485-489 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s0022215107008390 |
| Popis: | Objectives:The gold standard test for laryngopharyngeal reflux is 24-hour pH monitoring, which determines the reflux area index with a pH threshold of less than four (i.e. the reflux area index four). However, refluxed pepsin is able to cause laryngeal injury at pH levels above five.Study design:Prospective study.Materials and methods:In order to establish normative values for a reflux area index with a pH threshold of less than five (i.e. the reflux area index five), 29 healthy volunteers underwent pH monitoring. In 45 patients with suspected laryngopharyngeal reflux, reflux area index four and reflux area index five were determined by pH study.Results:In healthy volunteers, the reflux area index five was 72.6 (95th percentile). In 29 of 44 patients, laryngopharyngeal reflux was diagnosed due to a reflux area index four of greater than 6.3. However, the reflux area index five revealed laryngopharyngeal reflux in six more patients.Conclusions:For exact analysis of pH monitoring results, two pH thresholds (less than four and less than five) must be considered. Further studies with a larger number of healthy volunteers are necessary in order to reveal normative values for the reflux area index five parameter. |
| Databáze: | OpenAIRE |
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