Arterial Stiffness Preceding Diabetes
| Autor: | Shuohua Chen, Quanhui Zhao, Mengyi Zheng, Shouling Wu, Xiang Gao, Yongjian Song, Xinyuan Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male China medicine.medical_specialty Longitudinal study Time Factors Physiology Pulse Wave Analysis 030204 cardiovascular system & hematology Risk Assessment Article 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Ankle Brachial Index Longitudinal Studies Prospective Studies 030212 general & internal medicine Aged business.industry Incidence Middle Aged Prognosis medicine.disease Cardiovascular Diseases Cardiology Arterial stiffness Female Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Circ Res |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/circresaha.120.317950 |
| Popis: | Rationale: Previous studies on the relationship between diabetes and arterial stiffness were mostly cross-sectional. A few longitudinal studies focused on one single direction. Whether the association between arterial stiffness and diabetes is bidirectional remains unclear to date. Objective: To explore the temporal relationship between arterial stiffness and fasting blood glucose (FBG) status. Methods and Results: Included were 14 159 participants of the Kailuan study with assessment of brachial-ankle pulse wave velocity (baPWV) from 2010 to 2015, and free of diabetes, cardiovascular and cerebrovascular diseases, and chronic kidney disease at baseline. FBG and baPWV were repeatedly measured at baseline and follow-ups. Cox proportional hazard regression model was used to estimate hazard ratios and 95% confidence intervals (CIs) of incident diabetes across baseline baPWV groups: Conclusions: Arterial stiffness, as measured by baPWV, was associated with risk of developing diabetes. Arterial stiffness appeared to precede the increase in FBG. |
| Databáze: | OpenAIRE |
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