Microcirculatory alterations are associated with pulmonary dead-space fraction in moderate and severe ards
| Autor: | Juan David Valencia, Diego F. Bautista-Rincón, Gustavo A. Ospina-Tascón, Alejandro Bruhn, Humberto J. Madriñán, CE Salas, William F. Bermudez, Glenn Hernandez, Daniel De Backer |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology ARDS business.industry Acute respiratory distress Critical Care and Intensive Care Medicine medicine.disease Medical sciences Pathophysiology Hypoxemia Enfermedades respiratorias Hipoxemia Internal medicine Ciencias socio biomédicas Sistema respiratorio - Fisiopatologia Poster Presentation medicine Breathing Cardiology Enfermedades pulmonares medicine.symptom business Perfusion Pulmonary dead space |
| Zdroj: | Repositorio ICESI Universidad ICESI instacron:Universidad ICESI Intensive Care Medicine Experimental |
| Popis: | Shunt-induced hypoxemia i s considered the primary pathophysiological abnormality and main diagnostic cri- teria of acute respiratory distress syndrome (ARDS). However, increases in dead- space ventilation (VD/VT) can also contribute to gas exchange alterations in ARDS. Systemic microcirculatory alterations described during inflammatory conditions are characterized by perfusion heterogeneity and theoretically pulmonary microcirculatory heterogene ity could lead to imbalance pulmonary ventilation/perfusion relationship. Thus, we hypothesized that systemic microvascular alterations could reflect increased VD/VT in ARDS. |
| Databáze: | OpenAIRE |
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