Effect of Aminoguanidine on the Frequency of Neuroaxonal Dystrophy in the Superior Mesenteric Sympathetic Autonomic Ganglia of Rats With Streptozocin-Induced Diabetes
| Autor: | Lucie N. Beaudet, Karen M. Reiser, Robert E. Schmidt, Denise A. Dorsey, Ronald G. Tilton, Joseph R. Williamson |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Guanidines Diabetes Mellitus Experimental Rats Sprague-Dawley chemistry.chemical_compound Diabetic Neuropathies Glycation Diabetes mellitus Internal medicine Internal Medicine medicine Animals Enzyme Inhibitors Neurons Diabetic Autonomic Neuropathy Ganglia Sympathetic medicine.disease Axons Rats Streptozocin Microscopy Electron Autonomic nervous system Endocrinology Peripheral neuropathy medicine.anatomical_structure chemistry Peripheral nervous system Glycated hemoglobin Nitric Oxide Synthase |
| Zdroj: | Diabetes. 45:284-290 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/diab.45.3.284 |
| Popis: | Aminoguanidine, which prevents formation of advanced glycation end products and is a relatively selective potent inhibitor of the inducible (versus constitutive) isoform(s) of nitric oxide synthase, has been reported to ameliorate structural and functional abnormalities in peripheral somatic nerves in rats with streptozocin (STZ)-induced diabetes. In the present studies, the effects of aminoguanidine treatment on ultrastructural changes in the autonomic nervous system of rats with STZ-induced diabetes were examined. The frequency of neuroaxonal dystrophy, the neuropathological hallmark of sympathetic autonomic neuropathy in diabetic rats, increased 9- to 11-fold in the superior mesenteric ganglia of 7- and 10-month STZ-diabetic rats compared with that in age-matched controls. Administration of aminoguanidine continuously from the time of induction of diabetes at a dose equal to or in excess of that providing a salutary effect in the diabetic somatic peripheral nervous system did not alter the severity of diabetes as assessed by plasma glucose level, 24-h urine volume, and levels of glycated hemoglobin. Chronic aminoguanidine therapy did not diminish the frequency or affect the ultrastructural appearance of neuroaxonal dystrophy in diabetic or age-matched control rat sympathetic ganglia after 7 or 10 months of continuous administration. Our findings (under these experimental conditions) do not support a role for aminoguanidine-sensitive processes in the development of sympathetic neuroaxonal dystrophy in diabetic rats. Glycation-linked aminoguanidine-insensitive processes, however, such as the formation of early glucose adducts (Schiff bases and Amadori products) with intracellular and/or extracellular proteins and amine-containing lipids, superoxide anion generation during subsequent autoxidation of these glucose adducts, and non-glycative processes, remain potential pathogenetic mechanisms for diabetic autonomic neuropathy. |
| Databáze: | OpenAIRE |
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