The impact of hormone replacement therapy on metabolic syndrome components in perimenopausal women
| Autor: | Jugoslav Bagatin, Nina Berović Matulić, Ana Deković, Slaven Kokić, Sanja Baršić Ostojić, Betty Korljan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Risk
medicine.medical_specialty Hormone Replacement Therapy medicine.medical_treatment Population Early Therapy Models Biological Cohort Studies Insulin resistance Internal medicine medicine Humans education Cause of death education.field_of_study business.industry hormone replacement therapy metabolic syndrome perimenopausis Hormone replacement therapy (menopause) Estrogens General Medicine Models Theoretical medicine.disease Perimenopause Endocrinology Cardiovascular Diseases Research Design Cohort Women's Health Female sense organs Metabolic syndrome business Cohort study |
| Zdroj: | Medical hypotheses. 74(1) |
| ISSN: | 1532-2777 |
| Popis: | Hormone replacement therapy (HRT) is in use for more than a half of century, but the question of indications and ideal candidates for HRT remains unclear. Postmenopausal women are a population with the increasing risks for cardiovascular diseases which are the main cause of death in this group. Decline in oestrogen concentrations is linked to a number of changes in peri and postmenopause: increased total cholesterol, triglycerides, and low density lipoprotein, increased insulin resistance and impaired fibrinolysis. These changes are the main components of metabolic syndrome, the epidemic of the modern age. HRT is currently recommended as the gold standard for the management of vasomotor symptoms, but the benefit of HRT on components of metabolic syndrome and risk for cardiovascular events is still uncertain. In the initial reports from the Women's Health Initiative trial (WHI), overall health risks exceeded benefits in the cohort taking combined estrogen-progestin trial. Observational study in postmenopausal women, some meta-analyses and subsequent analyses of WHI had suggested that the timing of exposure to postmenopausal estrogen therapy may be an important factor in determining subsequent cardiovascular risk. It seems that the early therapy onset is a key factor in accomplishing positive results, but there are almost no surveys regarding the effects on the metabolic syndrome components in perimenopausal women. We hypothesized that the early, low dosage HRT in healthy perimenopausal women would have beneficial effects on the compounds of metabolic syndrome and could decrease the risk of cardiovascular events. Beneficial effect of HRT on cardiovascular diseases is due to the maintained integrity and functional status of the endothelium in younger women. We are aware of the fact that further studies are necessary to test the effects of different doses and routes of administration of HRT on cardiovascular outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect