Particle Therapy for Breast Cancer: Benefits and Challenges
| Autor: | Guangming Zhou, Caorui Liu, Xiaoni Jin, Ning-Ang Liu, Yasser F. Ali, Wanrong Luo, Chong Liu, Yuchen Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Mini Review medicine.medical_treatment particle treatment-associated challenges 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Internal medicine medicine proton therapy Particle beam Proton therapy RC254-282 Physics Particle therapy carbon ion radiotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Charged particle Hadron therapy Radiation therapy particle therapy 030220 oncology & carcinogenesis Carbon Ion Radiotherapy |
| Zdroj: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| Popis: | Hadron therapy with protons and carbon ions is widely attracting interest as a potential competitor of conventional photon radiotherapy. Exquisite dose distribution of charged particles allows for a higher local control of the tumor and lower probability of damage to nearby healthy tissues. Heavy ions have presumed biological advantages rising from their high-linear energy transfer (LET) characteristics, including greater cell-killing effectiveness and reduced heterogeneity dependence of radiation response. Although these advantages are clear and supported by data, only 18.0% of proton and carbon ion radiotherapy (CIRT) facilities in Europe are treating breast cancers. This review summarizes the physical and radiobiological properties of charged particles, clinical use of particle beam for breast cancer, and suggested approaches to overcome technical and financial challenges. |
| Databáze: | OpenAIRE |
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