Risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population living in Hong Kong
| Autor: | Samson Yun Sang Chan, Simon S M Hou, Peter K. F. Chiu, Chi-Fai Ng, Darren Ming Chun Poon, Jeremy Yuen-Chun Teoh, Ho Yuen Cheung |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Hyperlipidemias Comorbidity Kaplan-Meier Estimate urologic and male genital diseases Risk Assessment Brain Ischemia Androgen deprivation therapy Prostate cancer Asian People Risk Factors Diabetes mellitus Internal medicine Biomarkers Tumor Odds Ratio medicine Humans Radiology Nuclear Medicine and imaging Stroke Aged Neoplasm Staging Proportional Hazards Models Prostatectomy Gynecology business.industry Proportional hazards model Incidence Hazard ratio Prostatic Neoplasms Androgen Antagonists General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Radiation therapy Hypertension Hong Kong Neoplasm Grading business |
| Zdroj: | Japanese Journal of Clinical Oncology. 45:483-487 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | Objective: Previous reports on the risk of stroke after androgen deprivation therapy for prostate cancer were largely based on Caucasians. We investigated the risk of ischemic stroke after androgen deprivation therapy for prostate cancer in the Chinese population. Methods: All Chinese prostate cancer patients who were treated primarily with radical prostatectomy or radiotherapy, with (androgen deprivation therapy group) or without (non-androgen deprivation therapy group) further androgen deprivation therapy, at our hospital from year 2000–09 were reviewed. Potential risk factors of ischemic stroke including age, baseline prostate-specific antigen, Gleason score, clinical T stage, hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, history of stroke, use of androgen deprivation therapy and duration of androgen deprivation therapy were reviewed. The risk of ischemic stroke after androgen deprivation therapy was analyzed with Kaplan–Meier and multivariate Cox regression analyses. Results: A total of 452 patients were included, consisting of 200 patients in the non-androgen deprivation therapy group and 252 patients in the androgen deprivation therapy group. The androgen deprivation therapy group appeared to have increased risk of ischemic stroke when compared with the non-androgen deprivation therapy group (P = 0.063) upon Kaplan–Meier analysis. Upon multivariate Cox regression analyses, older age (hazard ratio 1.13, 95% confidence interval 1.04–1.22, P= 0.003), hyperlipidemia (hazard ratio 4.61, 95% confidence interval 2.01–10.54, P< 0.001) and the use of androgen deprivation therapy (hazard ratio 3.32, 95% confidence interval 1.14–9.67, P = 0.028) were associated with increased risk of ischemic stroke. Conclusions: There was increased risk of ischemic stroke afterandrogen deprivation therapy for prostate cancer in the Chinese population. The riskof ischemic stroke should be considered while deciding on androgen deprivation therapy, especially in older patients with known history of hyperlipidemia. |
| Databáze: | OpenAIRE |
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