Agonist activation of 5-HT1A receptors in the median raphe nucleus and female rat lordosis behavior
| Autor: | Lynda Uphouse, Sharmin Maswood, Marjay Caldarola-Pastuszka |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Agonist
Serotonin medicine.medical_specialty Median raphe nucleus Lordosis medicine.drug_class Sexual Behavior Animal Internal medicine medicine Animals Receptor Molecular Biology 8-Hydroxy-2-(di-n-propylamino)tetralin Chemistry General Neuroscience Amphetamines Rats Inbred Strains medicine.disease Lordosis behavior Rats Serotonin Receptor Agonists Ventromedial nucleus of the hypothalamus Endocrinology Ventromedial Hypothalamic Nucleus Raphe Nuclei 5-HT1A receptor Female Proestrus Neurology (clinical) Raphe nuclei Developmental Biology |
| Zdroj: | Brain Research. 668:271-275 |
| ISSN: | 0006-8993 |
| Popis: | Proestrous rats were infused unilaterally into the median raphe nucleus with 200–2,000 ng of the 5-HT 1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Inhibition of the lordosis to mount ratio occurred within 15 and 10 min, respectively, following infusion with 1,000 or 2,000 ng of the drug. Infusion of 2,000 ng of the 5-HT 2 agonist, (±)-2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or 4,000 ng 5-HT (creatinine sulfate) failed to substantially reduce lordosis behavior. |
| Databáze: | OpenAIRE |
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