Chromatin-nuclear membrane attachment in relation to DNA replication and chromosome aberrations: a new hypothesis
| Autor: | B.K. Vig |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Statistics and Probability
DNA Replication Somatic cell DNA Single-Stranded Biology In Vitro Techniques Deoxycytidine Models Biological General Biochemistry Genetics and Molecular Biology Chromosomes Chromosomal crossover Heterochromatin medicine Nuclear membrane Crosses Genetic Genetics Cell Nucleus Chromosome Aberrations Membranes General Immunology and Microbiology Applied Mathematics DNA replication Demecolcine Chromosome General Medicine Cell cycle Chromatin Radiation Effects medicine.anatomical_structure Doxorubicin Modeling and Simulation Chromosome breakage General Agricultural and Biological Sciences Colchicine |
| Zdroj: | Journal of theoretical biology. 54(2) |
| ISSN: | 0022-5193 |
| Popis: | A hypothesis is presented which explains chromosome breakage by considering possible relationship between chromatin material and nuclear membrane. It also explains the changes in sites of breaks in chromosomes by the same radiomimetic agent when applied during different phases of the cell cycle. It is discussed how some of the agents incapable of causing chromosome aberrations can (1) enhance the potential of radiomimetic agents in causing chromosome breakage and/or (2) reduce the possibility of somatic crossing over both at the genetic as well as the cytological level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|