Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine
| Autor: | Matthew C. Woodruff, Balthasar A. Heesters, Joanna R Groom, Michael C. Carroll, Shannon J. Turley, Caroline N. Herndon, Paul G. Thomas, Andrew D. Luster |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Receptors CXCR3 T cell Immunology Antigen presentation chemical and pharmacologic phenomena Biology Lymphocyte Activation Article Mice Immune system Antigen Orthomyxoviridae Infections Species Specificity Cell Movement medicine Immunology and Allergy Animals Cluster Analysis Antigens Viral B cell Antigen Presentation B-Lymphocytes Follicular dendritic cells Vaccination Immunity Germinal center Dendritic Cells Acquired immune system Orthomyxoviridae Virology 3. Good health Mice Inbred C57BL medicine.anatomical_structure Influenza Vaccines Lymph Lymph Nodes Chemokines Immunologic Memory |
| Zdroj: | Journal of experimental medicine, 211(8), 1611-1621. Rockefeller University Press The Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| DOI: | 10.1084/jem.20132327 |
| Popis: | Resident lymph node DCs rapidly locate viral influenza antigen to drive early activation of T cells, resulting in germinal center formation and B cell memory. Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective immunization. Although LNDCs have been implicated in immune response, their ability to directly drive effective immunity to lymph-borne antigen remains unclear. Using an inactive influenza vaccine model and whole node imaging approaches, we observed surprising responsiveness of LNDC populations to vaccine arrival resulting in a transnodal repositioning into specific antigen collection sites within minutes after immunization. Once there, LNDCs acquired viral antigen and initiated activation of viral specific CD4+ T cells, resulting in germinal center formation and B cell memory in the absence of skin migratory DCs. Together, these results demonstrate an unexpected stimulatory role for LNDCs where they are capable of rapidly locating viral antigen, driving early activation of T cell populations, and independently establishing functional immune response. |
| Databáze: | OpenAIRE |
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