Hypodiploidy is a major prognostic factor in multiple myeloma
| Autor: | Smadja, N V, Bastard, C, Brigaudeau, C, Leroux, D, Fruchart, C, Groupe Français de Cytogénétique Hématologique, Michaux, Lucienne, Libouton, J.M., Dumoulin, Christine, Scheiff, Jean-Marie, Deneys, Véronique, Ferrant, Augustin |
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| Přispěvatelé: | UCL - MD/MINT - Département de médecine interne, UCL - (SLuc) Service d'hématologie, UCL - MD/MNOP - Département de morphologie normale et pathologique, UCL - (SLuc) Service de biologie hématologique, UCL - (MGD) Service d'hématologie, UCL - (MGD) Centre de transfusion sanguine |
| Rok vydání: | 2001 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Pathology Immunology Chromosome Disorders Biology Biochemistry Risk Factors Immunopathology Internal medicine medicine Humans Prospective Studies Survival analysis Multiple myeloma Aged Aged 80 and over Chromosome Aberrations Analysis of Variance Cytogenetics Karyotype Cell Biology Hematology Middle Aged medicine.disease Prognosis Diploidy Survival Analysis Karyotyping Chromosome abnormality Hypodiploidy Female Ploidy Multiple Myeloma |
| Zdroj: | Blood, Vol. 98, no.7, p. 2229-2238 (2001) |
| ISSN: | 0006-4971 |
| Popis: | Conventional karyotypes performed before any treatment in 208 patients with multiple myeloma were reviewed by the Groupe Français de Cytogénétique Hématologique. A total of 138 patients displayed complex chromosomal abnormalities (CCAs). According to the chromosome number pattern, a first group of 75 patients had a hyperdiploid karyotype. A second group of 63 patients referred to as the hypodiploid group had either pseudodiploid, hypodiploid, or near-tetraploid karyotypes. Of 159 treated patients available for survival analysis, 116 had an abnormal karyotype. The comparison of overall survival (OS) between hyperdiploid and hypodiploid patients showed a highly significant difference (median OS 33.8 vs 12.6 months, respectively, P |
| Databáze: | OpenAIRE |
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