Clustering of the group III metabotropic glutamate receptor 4a at parallel fiber synaptic terminals in the rat cerebellar molecular layer
| Autor: | Pedro Grandes, Alexandra Osorio, Izaskun Elezgarai, Aurora Bilbao, Rocı́o Benı́tez, Jon Jatsu Azkue, Rainer Kuhn, Thomas Knöpfel, José María Mateos |
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| Rok vydání: | 1999 |
| Předmět: |
Cerebellum
Molecular Sequence Data Presynaptic Terminals Synaptic Membranes Parallel fiber AMPA receptor Biology Receptors Metabotropic Glutamate Transfection Antibodies Cell Line Rats Sprague-Dawley medicine Animals Humans Amino Acid Sequence Microscopy Immunoelectron Neurons General Neuroscience Metabotropic glutamate receptor 6 Glutamate receptor General Medicine Immunogold labelling Peptide Fragments Recombinant Proteins Rats medicine.anatomical_structure Metabotropic receptor Metabotropic glutamate receptor Biophysics Neuroscience |
| Zdroj: | Neuroscience Research. 35:71-74 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/s0168-0102(99)00066-8 |
| Popis: | We report in this study with a pre-embedding immunogold method, the clustering of the group III metabotropic glutamate receptor 4a (mGluR4a) along the presynaptic membrane of parallel fiber synaptic terminals in the cerebellar molecular layer. The mGluR4a clusters were homogeneously distributed and interspaced by about 60 nm. These results suggest a particular arrangement of mGluR4a which might help to a rapid and effective activation of this receptor by glutamate. |
| Databáze: | OpenAIRE |
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