Effect of prostaglandin F2α (PGF2α), indomethacin, tamoxifen or estradiol-17β on prostaglandin E (PGE), PGF2α and estradiol-17β secretion in 88 to 90-day pregnant sheep☆
| Autor: | Phillip J. Bridges, L. Kim, Yoshie S. Weems, B.R. LeaMaster, C.W. Weems, D.L. Vincent |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
Tocolytic agent medicine.medical_specialty Time Factors Physiology medicine.medical_treatment Indomethacin Estrogen receptor Prostaglandin Dinoprost Biochemistry Inferior vena cava chemistry.chemical_compound Pregnancy Internal medicine medicine Animals Pharmacology Sheep Estradiol business.industry Prostaglandins E Abortifacient Agents Steroidal Antagonist Abortion Induced Cell Biology Abortion Veterinary Tamoxifen Tocolytic Agents Endocrinology Prostaglandin F2alpha medicine.vein chemistry Pregnancy Animal Female lipids (amino acids peptides and proteins) business hormones hormone substitutes and hormone antagonists Prostaglandin E medicine.drug |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 58:167-178 |
| ISSN: | 1098-8823 |
| DOI: | 10.1016/s0090-6980(99)00036-2 |
| Popis: | Treatment with PGF2alpha plus estradiol-17beta aborts 90-day pregnant ewes, whereas PGF2alpha or estradiol-17beta alone does not abort ewes. The objective of this experiment was to evaluate whether tamoxifen, an estrogen receptor antagonist, estradiol-17beta, prostaglandin F2alpha (PGF2alpha), indomethacin, or some of their interactions affected ovine uterine/placental secretion of PGF2alpha, estradiol-17beta or prostaglandins E (PGE), because a single treatment with PGF2alpha and estradiol-17beta given every 6 h aborts 90-day pregnant ewes. Concentrations of PGF2alpha in uterine venous blood were increased (Por = 0.05) by estradiol-17beta, PGF2alpha + estradiol-17beta, and PGF2alpha + tamoxifen, and decreased (Por = 0.05) by indomethacin or PGF2alpha + indomethacin at 72 h when compared to the 0 h samples. Concentrations of PGE in uterine venous blood were decreased (Por = 0.05) by indomethacin and PGF2alpha + indomethacin and increased (Por = 0.05) by PGF2alpha + estradiol-17beta at 72 h when compared to the 0 h samples. Concentrations of PGF2alpha in inferior vena cava blood at 6 h were increased (Por = 0.05) by PGF2alpha either alone or in combination with indomethacin, tamoxifen, or estradiol-17beta, which is due to the PGF2alpha injected. Concentrations of PGF2alpha in inferior vena cava blood in PGF2alpha + estradiol-17beta-treated 88- to 90-day pregnant ewes increased (Por = 0.05) linearly over the 72-h sampling period and averaged 4.0 + 0.4 ng/ml. Concentrations of PGF2alpha in inferior vena cava blood of control, PGF2alpha, tamoxifen, PGF2alpha + indomethacin, PGF2alpha + tamoxifen, and estradiol-17beta-treated ewes did not differ (Por = 0.05) and averaged 0.4 + 0.04 ng/ml. Profiles of PGE in inferior vena cava blood of 88- to 90-day pregnant ewes treated with vehicle, PGF2alpha, estradiol-17beta, tamoxifen, tamoxifen + PGF2alpha, or estradiol-17beta + PGF2alpha did not differ (Por = 0.05). Concentrations of PGE in inferior vena cava blood of 88- to 90-day pregnant ewes treated with indomethacin or PGF2alpha + indomethacin were lower (Por = 0.05) than in control ewes. Concentrations of estradiol-17beta in jugular venous plasma of PGF2alpha + estradiol-17beta-treated 88- to 90-day pregnant ewes increased linearly and differed (Por = 0.05) from controls. Profiles of estradiol-17beta in jugular venous plasma of PGF2alpha, indomethacin, tamoxifen, and PGF2alpha + tamoxifen and PGF2alpha + indomethacin, estradiol-17beta, and controls did not differ (Por = 0.05). It is concluded that treatment with a single injection of PGF2alpha and estradiol-17beta given every 6 h causes a linear increase in PGF2alpha and estradiol-17beta. |
| Databáze: | OpenAIRE |
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