Reduced oxygen affinity contributes to improved oxygen releasing capacity during erythropoietin treatment of renal anaemia
| Autor: | Torbjörn Linde, Björn Wikström, C. H. de Verdier, B. Sandhagen, Bo G. Danielson, L. E. Bratteby |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia Population Blood viscosity chemistry.chemical_element Blood Pressure Blood volume Oxygen Internal medicine Humans Medicine education Erythropoietin Aged Whole blood 2 3-Diphosphoglycerate Transplantation education.field_of_study Blood Volume business.industry Middle Aged Blood Viscosity Diphosphoglyceric Acids medicine.disease Recombinant Proteins Endocrinology chemistry Nephrology Female Hemoglobin business medicine.drug |
| Zdroj: | Nephrology Dialysis Transplantation. 8:524-529 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/8.6.524 |
| Popis: | In addition to haemoglobin concentration, haemoglobin oxygen affinity plays a major role in the oxygen releasing capacity of the blood. In this study we have measured oxygen affinity as P50 and calculated the oxygen releasing capacity of blood from 10 haemodialysis patients treated with erythropoietin (rHuEpo). The patients were examined with different assays before start of treatment, after 11 weeks, and after 27 weeks. During the first phase of treatment the oxygen releasing capacity improved because of an increase in the haemoglobin concentration and P50. During the second phase there was a further significant increase in haemoglobin concentration, but due to a decrease in the P50 value the oxygen releasing capacity remained unchanged. Despite an unchanged oxygen releasing capacity and total blood volume, the antihypertensive treatment had to be increased during that phase of treatment. An increase in whole-blood viscosity may explain the increased need of antihypertensive drugs. The increase in P50 during the first phase of rHuEpo treatment can probably be explained by decreased mean age of the erythrocyte population and implies that the beneficial effect is greater than could be concluded from the increase in haemoglobin concentration. |
| Databáze: | OpenAIRE |
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