Prophylactic effects of olsalazine v sulphasalazine during 12 months maintenance treatment of ulcerative colitis. The Danish Olsalazine Study Group
| Autor: | P J Ranløv, T Rannem, S Kiilerich, K Ladefoged |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Danish Double-Blind Method Recurrence Sulfasalazine Internal medicine medicine Humans In patient Aged Antibacterial agent Olsalazine Chemotherapy business.industry Gastroenterology Middle Aged medicine.disease Ulcerative colitis Confidence interval language.human_language Surgery Aminosalicylic Acids language Colitis Ulcerative business Research Article medicine.drug |
| Zdroj: | Gut. 33:252-255 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.33.2.252 |
| Popis: | In a Danish multicentre trial we compared the relapse preventing effects of olsalazine and sulphasalazine in patients with ulcerative colitis over a 12 month treatment period. Two hundred and twenty seven patients (118 men) with at least two previous attacks of ulcerative colitis were randomly allocated according to a prearranged treatment schedule to olsalazine 500 mg bd or sulphasalazine 1 g bd in a double blind, double dummy fashion. One hundred and ninety seven patients completed the trial. The relapse rate after 12 month in the olsalazine group was 46.9% v 42.4% in the sulphasalazine group with a 95% confidence interval for the difference in proportions of -9% to 18%. Seven per cent of the patients were withdrawn from the trial because of adverse drug reactions and these were equally distributed between the two groups. |
| Databáze: | OpenAIRE |
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