The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
| Autor: | Martin A. Rooimans, Hans Joenje, Noa Alon, Maureen E. Hoatlin, de Groot J, Bosnoyan-Collins L, de Winter Jp, Fré Arwert, Christopher G. Mathew, Quinten Waisfisz, Jan C. Pronk, Yu Zhi, van Berkel Cg, Rik J. Scheper, van Der Weel L, Manuel Buchwald |
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| Přispěvatelé: | Human genetics, Pediatric surgery, Pathology, CCA - Cancer biology and immunology, AII - Cancer immunology, CCA - Imaging and biomarkers |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Fanconi anemia complementation group C DNA Complementary Molecular Sequence Data Biology Fanconi Anemia Complementation Group F Protein FANCF Fanconi anemia FANCG hemic and lymphatic diseases Chromosome instability FANCD2 Genetics medicine Humans Amino Acid Sequence Sequence Homology Amino Acid nutritional and metabolic diseases RNA-Binding Proteins medicine.disease Molecular biology FANCA Recombinant Proteins FANCB Fanconi Anemia |
| Zdroj: | King's College London de Winter, JP, Rooimans, MA, van der Weel, L, van Berkel, CGM, Alon, N, Bosnoyan-Collins, L, de Groot, J, Zhi, Y, Waisfisz, Q, Pronk, JC, Arwert, F, Mathew, CG, Scheper, RJ, Hoatlin, ME, Buchwald, M & Joenje, H 2000, ' The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM ', Nature Genetics, vol. 24, no. 1, pp. 15-16 . https://doi.org/10.1038/71626 Nature Genetics, 24(1), 15-16. Nature Publishing Group |
| ISSN: | 1061-4036 |
| Popis: | Fanconi anaemia (FA) is a chromosomal instability syndrome with autosomal recessive inheritance. We have identified the gene mutated in Fanconi anaemia group F patients by complementation cloning. FANCF has no introns and encodes a polypeptide with homology to the prokaryotic RNA binding protein ROM. |
| Databáze: | OpenAIRE |
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