Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model
| Autor: | Ahmed Al Subaie, Ola M. Maria, Jeff Phan, Marie Lordkipanidzé, Faez Saleh Al-Hamed, Osama A Elkashty, Imane Boukhatem, Faleh Tamimi, Zahi Badran, Qiman Gao, Lina Abu Nada, Simon D. Tran, Alaa Mansour |
|---|---|
| Přispěvatelé: | Université de Montréal. Faculté de pharmacie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment lcsh:QR1-502 Bone healing Metaphysis Biochemistry lcsh:Microbiology Osseointegration Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Bone-Implant Interface mental disorders medicine Animals Donepezil Molecular Biology Saline Titanium Wound Healing Tibia business.industry Soft tissue osseointegration 030206 dentistry X-Ray Microtomography Rats donepezil Tibial Fractures medicine.anatomical_structure Acetylcholinesterase inhibitor acetylcholinesterase inhibitors Anesthesia Bone Substitutes hemostasis Female Implant Cholinesterase Inhibitors bone healing business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Biomolecules Volume 10 Issue 9 Biomolecules, Vol 10, Iss 1318, p 1318 (2020) |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom10091318 |
| Popis: | Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |