Possible role of p53/Mieap‐regulated mitochondrial quality control as a tumor suppressor in human breast cancer
| Autor: | Siqin Gaowa, Kazuhiro Yoshida, Manabu Futamura, Hiroki Kamino, Jesse Yu Tajima, Masayuki Tsuneki, Hirofumi Arakawa, Ryutaro Mori |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cytoplasm Cancer Research Colorectal cancer Apoptosis law.invention law Promoter Regions Genetic skin and connective tissue diseases Aged 80 and over Carcinoma Ductal Breast General Medicine Middle Aged Phenotype Mitochondria Gene Expression Regulation Neoplastic Oncology Caspases MCF-7 Cells Immunohistochemistry Female Original Article Adult caspase Breast Neoplasms promoter methylation Disease-Free Survival Mitochondrial Proteins 03 medical and health sciences breast cancer Breast cancer Clinical Research Cell Line Tumor medicine Humans Aged business.industry Cancer Original Articles DNA Methylation Ductal carcinoma medicine.disease 030104 developmental biology Mieap Mutation Cancer research Suppressor Tumor Suppressor Protein p53 business |
| Zdroj: | Cancer Science |
| ISSN: | 1349-7006 1347-9032 |
| Popis: | Mitochondria‐eating protein (Mieap), encoded by a p53‐target gene, plays an important role in mitochondrial quality control (MQC). Mieap has been reported to have a critical role in tumor suppression in colorectal cancer. Here, we investigated its role as a tumor suppressor in breast cancer. The enforced expression of exogenous Mieap in breast cancer cells induced caspase‐dependent apoptosis, with activation of both caspase‐3/7 and caspase‐9. Immunohistochemistry revealed endogenous Mieap in the cytoplasm in 24/75 (32%) invasive ductal carcinomas (IDC), 15/27 (55.6%) cases of ductal carcinoma in situ (DCIS) and 16/18 (88.9%) fibroadenomas (FA) (IDC vs DCIS; P = 0.0389, DCIS vs FA; P = 0.0234, IDC vs FA; P |
| Databáze: | OpenAIRE |
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