Microbiology of bacterial translocation in humans
| Autor: | C. J. O’Boyle, C J Mitchell, P. C. Sedman, P. M. Sagar, D Johnstone, John MacFie |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Adolescent medicine.medical_treatment Chromosomal translocation Biology Microbiology Sepsis Postoperative Complications Laparotomy Escherichia coli Prevalence medicine Humans Mesenteric lymph nodes Lymph node Aged Aged 80 and over Bacteriological Techniques Gastroenterology Bacterial Infections Middle Aged medicine.disease biology.organism_classification medicine.anatomical_structure Bacterial Translocation Small Intestine Female Lymph Nodes Animal studies Lymph Bacteria |
| Zdroj: | Gut. 42:29-35 |
| ISSN: | 1468-3288 0017-5749 |
| DOI: | 10.1136/gut.42.1.29 |
| Popis: | Background—Gut translocation of bacteria has been shown in both animal and human studies. Evidence from animal studies that links bacterial translocation to the development of postoperative sepsis and multiple organ failure has yet to be confirmed in humans.Aims—To examine the spectrum of bacteria involved in translocation in surgical patients undergoing laparotomy and to determine the relation between nodal migration of bacteria and the development of postoperative septic complications.Methods—Mesenteric lymph nodes (MLN), serosal scrapings, and peripheral blood from 448 surgical patients undergoing laparotomy were analysed using standard microbiological techniques.Results—Bacterial translocation was identified in 69 patients (15.4%). The most common organism identified wasEscherichia coli (54%). Both enteric bacteria, typical of indigenous intestinal flora, and non-enteric bacteria were isolated. Postoperative septic complications developed in 104 patients (23%). Enteric organisms were responsible in 74% of patients. Forty one per cent of patients who had evidence of bacterial translocation developed sepsis compared with 14% in whom no organisms were cultured (pConclusion—Bacterial translocation is associated with a significant increase in the development of postoperative sepsis in surgical patients. The organisms responsible for septic morbidity are similar in spectrum to those observed in the mesenteric lymph nodes. These data strongly support the gut origin hypothesis of sepsis in humans. |
| Databáze: | OpenAIRE |
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