Negative association between plasma levels of adiponectin and polychlorinated biphenyl 153 in obese women under non-energy-restrictive regime
| Autor: | J Rosmus, Frantisek Sefrna, Ondrej Kuda, D Matejkova, M Matejovic, Sylvie Opatrná, Luděk Müller, Dana Müllerová, Jan Kopecky, Jaroslav Racek |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Type 2 diabetes Body Mass Index Young Adult chemistry.chemical_compound Internal medicine Blood plasma medicine Humans Insulin Longitudinal Studies Obesity Pancreatic hormone Aged Caloric Restriction Czech Republic Nutrition and Dietetics Adiponectin business.industry Polychlorinated biphenyl Middle Aged medicine.disease Polychlorinated Biphenyls Endocrinology chemistry Case-Control Studies Environmental Pollutants Female business Body mass index Biomarkers |
| Zdroj: | International Journal of Obesity. 32:1875-1878 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/ijo.2008.169 |
| Popis: | The aim of this study was to reveal whether accumulation of the persistent organic pollutants (POPs), especially polychlorinated biphenyl (2,2',4,4',5,5'-hexachlorobiphenyl, PCB 153), affects plasma levels of adiponectin in obese patients. The study was designed as a longitudinal intervention trial with a control group, where 27 obese women (body mass index (BMI)30 kg/m(2); age 21-74 years) were studied before (OB) and after (OB-LCD) a 3-month low-calorie-diet intervention (LCD; 5 MJ daily). As the control group, 9 female volunteers without LCD intervention were used (C; BMI=19-25 kg/m(2); age 21-64 years). Plasma levels of PCB 153 were measured by high-resolution gas chromatography with electron capture detection; total adiponectin and insulin plasma levels were quantified by immunoassays; and adiponectin multimeric complexes were quantified by immunoblotting. Plasma levels of total adiponectin, high and medium molecular weight multimers significantly negatively correlated with plasma levels of PCB 153 in OB, but not in C or in OB-LCD, whereas the LCD intervention lowered BMI by 3.3+/-3.0 kg/m(2). Our results may suggest suppression of adiponectin by PCB 153 in obese women under non-energy-restrictive regime, which may contribute to the known association of PCB 153 and other POPs with type 2 diabetes. |
| Databáze: | OpenAIRE |
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