Structure-activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels

Autor:	Alshaima'a M. Qunies, Nigam M. Mishra, Brittany D. Spitznagel, Yu Du, Valerie S. Acuña, C. David Weaver, Kyle A. Emmitte
Rok vydání:	2022
Předmět:	Potassium Channels Organic Chemistry Clinical Biochemistry Pharmaceutical Science Nerve Tissue Proteins Potassium Channels Sodium-Activated Biochemistry Structure-Activity Relationship HEK293 Cells Drug Discovery Molecular Medicine Humans Thallium Molecular Biology
Zdroj:	Bioorganicmedicinal chemistry letters. 76
ISSN:	1464-3405
Popis:	In this Letter we describe structure-activity relationship (SAR) studies conducted in five distinct regions of a new 2-amino-N-phenylacetamides series of Slack potassium channel inhibitors exemplified by recently disclosed high-throughput screening (HTS) hit VU0606170 (4). New analogs were screened in a thallium (Tl
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf246d3f681274747c32621e15715f87 https://pubmed.ncbi.nlm.nih.gov/36184030 Zobrazit plný text záznamu Full Text from ScienceDirect